The Midwest is refining the innovation process by bringing together academia and defense partners to solve national security challenges. Dual-use technologies that can serve commercial and defense applications are hot in the Midwest. Universities from Wisconsin, Ohio, Indiana, Illinois, Missouri and Iowa represent the Midwest to advance innovation on a national scale. T-REX is home to the nation’s first geospatial innovation center and Moonshot Labs. The future is bright for American defense innovation as entrepreneurs and national labs develop dual-use technologies with support from academia.